Thanks to enormous progress in sequencing of genome data currently we know millions of protein sequences. At the same time, due to costly and difficult procedures, the number of experimentally solved protein structures is much smaller, ca. 60,000. Thus, theoretical, in silico, prediction of protein structures and dynamics is essential for understanding the molecular basis of drug action, metabolic and signaling pathways in living cells, designing new technologies in the life science and material sciences. The next and even more challenging step in structural genomics is the determination of protein complexes, needed to have a complete molecular-level understanding of a protein function.
Selvita Protein Modeling Platform (SPMP) is a new kind, web-based, protein modeling tool, built on the idea that the protein modeling can be more user-friendly and practical. The SPMP is designed for protein modelers and biologists, who want to use protein and protein assembly structure information in a drug design or in studies of molecular mechanisms.
Starting with the homology modeling set of tools along with unique structure prediction from sequence-only and protein-protein docking capabilities, the SPMP allows researchers to obtain comparative views of protein structure data and their binding modes they need to understand.
The Platform features: - superior protein structure prediction capabilities at all the difficulty levels (homology modeling, fold recognition, de novo folding), based on unique CASP competition-winning technology
- protein-protein docking comprising rigid-body protein-protein docking, fully flexible protein-protein docking and protein complexes structural filtering
- remote web access (client – server architecture)
- pay-per-use possibility of usage, no local software installation required
|  Protein structure visualization and verification  Protein modeling input (alignment) preparaton  Protein structure analysis
 SPMP predicted and experimentally derived conformation of an active-site loop (13 residues long: 81-93) of human serine/ threonine-protein kinase MST4 (PDB ID: 3GGF). The RMSD between the ab-initio predicted (blue) and the native (gray) loops is 1.35 A |