Protein kinase studies
Selvita offers complex quantitative Protein Kinase Kinetics Studies involving performance of quantitative measurement of protein kinase kinetic activities (PKA studies) in vitro, such as:
- Custom kinase production and purification (medium to large scale)
- In vitro kinase assays (Multiplex, robotized platform, competition assays)
- Screening inhibition of kinase enzymatic activities by competition assays using multiplex reactions
- Determination of selectivity for multi-kinase inhibitors
- Bioinformatics-supported rational small molecule inhibitors design
- Validating computationally predicted or other types of kinase substrate peptide candidates
- Mapping of kinase substrate specificity
- Identifying substrate peptides as biomarkers
- Crystallization of kinase targets (incl. soaking in inhibitors)
- Target phosphoprotein and downstream pathways analysis in cells (WB, ELISA, Flow cytometry)
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