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Selvita signs a drug discovery services contract with Rottapharm Madaus
Tuesday, 20 July 2010
Rottapharm Madaus , the multinational  pharmaceutical company, has signed a drug discovery research contract with Selvita  -  Poland based product and solution provider for the pharmaceutical and biotechnology industry.

Krakow, 20 July 2010
- Rottapharm Madaus and Selvita announced today signature of a services contract for delivery of drug discovery services. The aim of this project is to deliver to Rottapharm Madaus a set of designed and synthesized compounds, including their optimized synthesis route, which will have a therapeutic potential in an indicated area.

We are delighted to start an FTE-based collaboration with Selvita. We are keen to take advantage of  Selvita’s know-how to support the progression of our drug discovery pipeline  – said Luigi Stasi, Rottapharm’s Director of Medicinal Chemistry Department. We are looking forward to a very fruitful and effective cooperation."
 
"We are very pleased and honoured that we can cooperate with such a prestigious multinational pharmaceutical company as Rottapharm Madaus – said Paweł Przewięźlikowski, Selvita’s CEO. This project is an immense chance for Selvita to show the great potential of our Computational Chemistry and Chemistry Departments. Working for Rottapharm Madaus on this project will enable us to take a full advantage of our highly skilled scientists and new facilities, and I truly believe we can deliver exactly what Rottapharm Madaus needs. I’m looking forward to this cooperation very much.”


Rottapharm is a multinational pharmaceutical company with Italian capital, established in Monza, Italy in 1961. Since its beginning, Rottapharm was characterized by a strong commitment to research: in almost 50 years,  Rottapharm ‘s scientists synthesized thousands lead compounds on specific molecular targets, generating more than 300 patents and 19 original drugs. Rottapharm R&D is focused on therapeutic areas such as: rheumatology, gynaecology, urology, gastroenterology, bronchopneumology, psychiatry, oncology. In 2000, through the acquisition of major brands in intimate hygiene and paediatric care, such as the Saugella and Babygella brands, Rottapharm has entered the personal care market  in the pharmacy, further strengthening  its position thereafter. In 2007, Rottapharm performed the largest M & A transaction ever made by an Italian pharmaceutical company, through the acquisition of the German group Madaus Pharma.

Selvita Group is  a Polish, privately-owned, biotechnology company engaged in the drug discovery, as well as in the drug discovery services. The company was established in 2007, and currently employs almost 100 scientists, including 33 PhDs. Since 2008, Selvita is also the main shareholder of BioCentrum, which provides in-vitro preclinical ADMET services, biochemistry services with special focus on protein engineering and antibody development. Selvita Group provides services in the following areas:
-    Integrated drug discovery projects which include in silico modeling, and synthesis of a target-focused library, lead-optimization and preclinical development;
-    Chemistry services, including contract synthesis, synthesis pathway design and optimization, analytical chemistry, as well as computational chemistry services;
-    Biology services, including assay development such as ELISA and cytotoxicity assays, spectrophotometric, fluorescence and fluorescence anisotropy measurements, as well as cell cycle arrest analysis and apoptosis/necrosis identification; and
-    Advanced protein modeling solutions, based on our proprietary protein modeling platform, as well as services in computational chemistry.
For more information about the project or the company, please contact: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it   

Media contact:
Natalia Pawela
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mobile: 784 069 418
 
Selvita and Orion Pharma will collaborate on SEL103 - Alzheimer's disease program
Thursday, 08 July 2010
Place:     Kraków (Poland), Espoo (Finland)
Date:     8 July 2010
Categories:    Collaborations & licensing

SUMMARY
Orion Corporation and Selvita have agreed to collaborate on further research and development of Selvita’s  SEL103 program, for the symptomatic treatment of Alzheimer’s disease. The agreement provides for an initial up-front payment to Selvita from Orion, as well as research funding and additional milestone payments based on the successfulness of the development of the compound in multiple cognitive disorder indications.

FULL STORY
Selvita sp. z o.o., from Krakow, Poland and Orion Corporation from Espoo, Finland (ORNBV) today announced that they have entered into a global collaboration to jointly develop and commercialize SEL103, Selvita’s proprietary program for the treatment of Alzheimer’s disease and other cognitive disorders. Selvita will be responsible for early research on the program and Orion will take over the pre-clinical and clinical development as well as further commercialization.

Under the terms of the agreement, Selvita will be responsible for the discovery and early preclinical development of small molecules and will receive upfront and research funding as well as milestone payments from Orion subject to the progress of the development program. After the selection of a lead compound, Orion will be responsible for the further steps of the program with global commercialization rights. The financial and other details of the collaboration agreement remain between the parties.

"Neurodegenerative diseases with cognitive dysfunctions are a major global disease burden. The joint program combines synergistically the capabilities of both companies providing new opportunities with a clear aim to develop improved medicines for patients with Alzheimer’s disease and related disorders”. said Dr. Jukka Sallinen, Head of CNS Research of Orion.  

The joint program with Selvita is highly in line with our strategy of entering into early stage collaboration with partners having complementary skills to our own activities. In addition to competence, we have seen high enthusiasm and commitment to the collaboration in Selvita.  With these assets, we can look forward to a good and fruitful relationship”, said Dr. Antti Haapalinna, Vice President, Research, R&D of Orion.

The companies are planning to conduct a broad-based global research and development program which will combine the resources of Orion’s experienced CNS research and development team with Selvita’s competencies in discovery chemistry and biology assays. In collaboration, both parties can achieve joint goals faster and with better success than by doing the work alone.

We are excited to have the opportunity to collaborate with Orion – one of the leading pharmaceutical companies dedicated to developing and commercializing central nervous system drugs, with significant experience in conducting clinical trials in neuropsychiatric disorders which will benefit the most from our program" said Pawel Przewiezlikowski, the Chief Executive Officer of Selvita, "From the start of Selvita in 2007, our top priority has been to establish partnerships that will help us translate the vision of our scientists and academic collaborators and allow us to realize our strategy of becoming an integrated drug discovery company."
We are delighted to see that Orion entrusts our expertise to progress into full clinical development more quickly than current industry norms,” added Dr. Nicolas Beuzen, the Chief Scientific Officer of Selvita.

About ALZHEIMER’S
Alzheimer's disease is the most common cause of dementia. Dementia is a collective name for progressive degenerative brain syndromes which affect memory, thinking, behaviour and emotion. Although there are no drugs that can cure Alzheimer's disease, there are some treatments that can help people with Alzheimer's disease. However, better drug treatments are needed, especially due to the aging of human population. Currently there are an estimated 30 million people worldwide with dementia. Two thirds of them live in developing countries. This figure is set to increase to more than 100 million people by 2050. Much of this increase will be in rapidly developing and heavily populated regions such as China, India and Latin America (according to Alzheimer’s Disease International, ADI).

About SEL103
Selvita’s SEL103 program is based on novel, orally bioavailable and highly selective small-molecules which have the potential to play role in the treatment of multiple cognitive disorders, including Alzheimer’s disease, dementias, etc. SEL103 is expected to enter formal pre-clinical development shortly.

About SELVITA
SELVITA is a Polish, privately-owned, biotechnology company engaged in the discovery and development of breakthrough medicines to treat CNS, oncology and autoimmune disorders as well as provision of non-clinical research services. It was established and 2007 and currently employs 96 scientists, including 33 PhDs. SELVITA has currently several projects at early or late discovery stage and is expected to move its first candidates to the clinic in 2012. The most advanced programs at Selvita are SEL103 for the symptomatic treatment of Alzheimer’s disease and SEL24, a pre-clinical Pim kinase inhibitor, with multiple indications in solid and hematopoietic tumors. Additional information about SELVITA can be found on the Internet at http://www.selvita.com.

About ORION
Orion is an innovative European R&D-based pharmaceutical and diagnostic company with a special emphasis on developing medicinal treatments and diagnostic tests for global markets. Orion develops, manufactures and markets human and veterinary pharmaceuticals, active pharmaceutical ingredients and diagnostic tests. Orion’s pharmaceutical R&D focuses on the following core therapy areas: central nervous system drugs, cancer and critical care drugs, and Easyhaler® pulmonary drugs. The Group’s net sales in 2009 amounted to EUR 772 million. The Company invested EUR 95 million in research and development. At the end of 2009, the Group had a total of 3,100 employees, of whom 2,500 worked in Finland and 600 in other European countries. Orion’s A and B shares are listed on NASDAQ OMX Helsinki. Orion’s corporate website is at http://www.orion.fi

SELVITA Forward-looking Statement
This press release contains "forward-looking statements," including statements related to the potential value of payments, which may be received pursuant to our collaboration with ORION and the anticipated development of SEL103 pursuant to the collaboration in CNS disorders, and the future responsibilities of the parties under the collaboration agreements. Forward-looking statements are based on management's expectations and are subject to certain factors, risks and uncertainties that may cause actual results, outcome of events, timing and performance to differ materially from those expressed or implied by such statements. These risks and uncertainties include, but are not limited to, the costs associated with our research, development, manufacturing and other activities, the conduct and results of pre-clinical and clinical studies of our product candidates, difficulties or delays in obtaining regulatory approvals to market products resulting from our development efforts, our reliance on partners, including Orion, and other key parties for the successful development, manufacturing and commercialization of products, the adequacy of our capital resources and the availability of additional funding, patent protection and third-party intellectual property claims relating to our and any partner's product candidates, the timing, scope, cost and outcome of legal and patent office proceedings concerning our patent portfolio, future capital needs, key employees, markets, economic conditions, prices, reimbursement rates, competition and other factors The information contained in this document is believed to be current as of the date of original issue. The Company does not intend to update any of the forward-looking statements after the date of this document to conform these statements to actual results or to changes in the Company's expectations, except as required by law.

Contacts:

SELVITA
Natalia Pawela
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Selvita sp. z o. o.
ul. Bobrzynskiego 14,
30-348 Krakow
Poland
tel: +48 12 297 47 00
fax +48 12 297 47 01

Orion
Dr. Antti Haapalinna
VP, Research, Pharmaceutical R&D
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Selvita has released the most recent results of its SEL24 oncology program
Wednesday, 14 April 2010
Kraków, Poland – April 14, 2010 – Selvita has released the most recent results of its SEL24 oncology program.

In vitro and in vivo evaluation of an optimized series of compounds was performed.
 
Dr. Nicolas Beuzen, Selvita’s CSO commented about the results:
In order to improve the potency and selectivity of the original compound, a series of new derivatives was synthesized and screened for Pim-1 inhibition. Among the newly synthesized compounds several exerted increased potency in Pim-1 inhibition with IC50 values below 5 nM, confirmed in biomarkers studies.  Moreover, our recent in vivo experiments showed substantial tumor growth inhibition in leukemia models.”

Pim kinases are one of the most interesting new therapeutic targets which are being currently researched by the biggest pharmaceutical companies in the world. According to the most recent literature reviews Pim kinases are strongly related to the process of oncogenesis and development of leukemias, prostate cancer, breast cancer, pancreatic cancer, renal cancer and glioblastomas.

SEL24 is the major oncology program that Selvita currently has in its pipeline, first-in-human application for SEL24 is planned for 2011.


About Selvita
Selvita delivers comprehensive solutions to customers from the pharmaceutical and biotechnology industry targeted at lowering the cost of introducing innovative compounds to the market. The areas of our activity include: advanced protein modeling services and software;  computer aided drug design; optimization of lead compounds; contract synthesis;
information technology for research projects. Selvita also conducts its own innovative research projects for the pharmaceuticals customers, in collaboration with various leading research institutions.
Currently projects being developed are in the area of oncology and central nervous system.

For more information about the project or the company, please contact: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

 
 
Selvita featured in Life Science Clusters
Monday, 08 June 2009
Selvita featured in the Life Science Clusters 2009 issue from BIO International Convention.
Read more
 
Selvita featured in Nature Biotechnology
Thursday, 26 March 2009
Selvita has been featured in the Nature Biotechnology journal :
Volume 27, Number 1, January 2009.

Read more


 
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